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Biological properties and clinical applications of berberine

Danyang Song, Jianyu Hao, Daiming Fan

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 564-582 doi: 10.1007/s11684-019-0724-6

Abstract: , an isoquinoline alkaloid isolated from the Chinese herb and other plants, has a wide range of pharmacologicalproperties.This article summarizes the main pharmacological actions of berberine and its mechanisms in cancer and

Keywords： berberine     Coptis chinensis     pharmacological properties     mechanism     clinical applications    

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Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 564-574 doi: 10.1007/s11684-018-0676-2

Abstract: Traditional Chinese medicine (TCM) formulas have attracted increasing attention worldwide in the past few years for treating complex disease including rheumatoid arthritis. However, their mechanisms are complex and remain unclear. Guan-Jie-Kang (GJK), a prescription modified from “Wu Tou Decoction,” was found to significantly relieve arthritis symptoms in rats with adjuvant-induced arthritis after 30-day treatment, especially in the 24 g/kg/day group. By analyzing 1749 targets related to 358 compounds in the five herbs of GJK, we identified the possible anti-arthritis pathways of GJK, including the calcium signaling and metabolic pathways. Bone damage levels were assessed by micro-computed tomography, and greater bone protective effect was observed with GJK treatment than with methotrexate. Receptor activator of nuclear factor κB ligand (RANKL)–RANK signaling, which is related to calcium signaling, was significantly regulated by GJK. Moreover, a target metabolomics assay of serum was conducted; 17 metabolic biomarkers showed significant correlations with treatment. An integrated pathway analysis revealed that pyruvate metabolism, purine metabolism, and glycolysis metabolism were significantly associated with the effects of GJK in arthritis treatment. Thus, this study establishes a new omics analytical method integrated with bioinformatics analysis for elucidating the multi-pathway mechanisms of TCM.

Keywords： rheumatoid arthritis     traditional Chinese medicine     pharmacological mechanism     metabolism     adjuvant-induced    

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Cell Therapy: Pharmacological Intervention Enters a Third Era

Wei He

Engineering 2019, Volume 5, Issue 1,   Pages 5-9 doi: 10.1016/j.eng.2018.11.017

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A novel intravenous general anesthetic--- emulsified isoflurane: from bench to bedside

Cheng Zhou, Jin Liu

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 381-387 doi: 10.1007/s11684-012-0229-z

Abstract: anesthesia to various fields including regional anesthesia, organ protection, as well as anesthetic pharmacological

Keywords： emulsified isoflurane (EI)     general anesthesia     regional anesthesia     organ protection     anesthetic pharmacological    

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design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 277-284 doi: 10.1007/s11684-018-0630-3

Abstract: The development of new proton-pump inhibitors (PPIs) with less adverse effects by lowering the pKa values of nitrogen atoms in pyrimidine rings has been previously suggested by our group. In this work, we proposed that new PPIs should have the following features: (1) number of ring II= number of ring I+ 1; (2) preferably five, six, or seven-membered heteroatomic ring for stability; and (3) 1

Keywords： proton-pump inhibitor     adverse effect     pharmacological mechanism     toxicological mechanism     pKa calculation    

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Effect of different high viscosity modifiers on rheological properties of high viscosity asphalt

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 6,   Pages 1390-1399 doi: 10.1007/s11709-021-0775-z

Abstract: The purpose of this study was to investigate the rheological properties of HVA prepared using different

Keywords： high viscosity asphalt     rheological properties     rubber     modifier     viscosity    

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LINKING CROP WATER PRODUCTIVITY TO SOIL PHYSICAL, CHEMICAL AND MICROBIAL PROPERTIES

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4,   Pages 545-558 doi: 10.15302/J-FASE -2020349

Abstract: As the medium for crop growth, soils and their properties are important in affecting crop water productivityThis review examines the effects of soil physical, chemical, and microbial properties on crop water productivity

Keywords： crop water productivity     crop yield     soil chemical properties     soil microbial properties     soil physicalproperties     water consumption    

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Effect of earth reinforcement, soil properties and wall properties on bridge MSE walls

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1209-1221 doi: 10.1007/s11709-021-0764-2

Abstract: Mechanically stabilized earth (MSE) retaining walls are popular for highway bridge structures. They have precast concrete panels attached to earth reinforcement. The panels are designed to have some lateral movement. However, in some cases, excessive movement and even complete dislocation of the panels have been observed. In this study, 3-D numerical modeling involving an existing MSE wall was undertaken to investigate various wall parameters. The effects of pore pressure, soil cohesion, earth reinforcement type and length, breakage/slippage of reinforcement and concrete strength, were examined. Results showed that the wall movement is affected by soil pore pressure and reinforcement integrity and length, and unaffected by concrete strength. Soil cohesion has a minor effect, while the movement increased by 13–20 mm for flexible geogrid reinforced walls compared with the steel grid walls. The steel grid stresses were below yielding, while the geogrid experienced significant stresses without rupture. Geogrid reinforcement may be used taking account of slippage resistance and wall movement. If steel grid is used, non-cohesive soil is recommended to minimize corrosion. Proper soil drainage is important for control of pore pressure.

Keywords： mechanically stabilized earth walls     precast concrete panels     backfill soil     finite element modeling     earth reinforcement    

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Mechanical properties and microstructure of multilayer graphene oxide cement mortar

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 4,   Pages 1058-1070 doi: 10.1007/s11709-021-0747-3

Abstract: This study reports on the effects of multilayer graphene oxide (MGO) on compressive strength, flexural strength, and microstructure of cement mortar. The cement mortar was prepared with type P. II. 52.5 Portland cement, standard sand, and MGO. Four mixes were prepared with inclusion of MGO (0%, 0.02%, 0.04%, and 0.06% by weight of cement). The testing result shows that the compressive of GO-cement mortar increased by 4.84%–13.42%, and the flexural strength increased by 4.37%–8.28% at 3 d. GO-cement mortar’s compressive strength and flexural strength at 7 d increased by 3.84%–12.08% and 2.54%–13.43%, respectively. MGO made little contribution to the increases of compressive strength and flexural strength of cement mortar at 28 d. The results of X-ray diffraction (XRD), scanning electron microscope (SEM), and nitrogen (N2) adsorption/desorption tests show that the types of hydration products and crystal grain size did not change after adding MGO. Still, it can help to improve the microstructure of the cement mortar via regulating hydration products and can provide more condensed cores to accelerate hydration. Furthermore, the regulating action of MGO for the microstructure of cement mortar at an early age was better than that at 28 d.

Keywords： graphene oxide     cement     mortar     mechanical properties     microstructure    

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Synthesis, characterization and assessment thermal properties of clay based nanopigments

Mohammad Banimahd KIEVANI, Milad EDRAKI

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 1,   Pages 40-45 doi: 10.1007/s11705-015-1505-7

Abstract: nano-particles, and have already been used in polymeric coatings to improve mechanical thermal and stability properties

Keywords： nanopigment     layered silicate     cationic dye     thermal properties    

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Aging properties and aging mechanism of activated waste rubber powder modified asphalt binder based onrheological properties and micro-characterization

Frontiers of Structural and Civil Engineering 2023, Volume 17, Issue 4,   Pages 625-636 doi: 10.1007/s11709-023-0938-1

Abstract: Subsequently, the aging properties and aging mechanism of activated waste rubber powder modified asphalt(ARMA) are investigated based on its rheological properties and micro-characterization.

Keywords： rubber powder modified asphalt     aging     mechanism     rheological     characterization    

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Mechanical properties of vanadium-alloyed austempered ductile iron for crankshaft applications

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 3, doi: 10.1007/s11465-023-0746-2

Abstract: focused on the development of austempered ductile iron (ADI) with desirable combination of mechanical propertiesbainitic structures were obtained, which led to the formation of diverse combinations of mechanical propertiesThe mechanical properties of the austempered samples were tested comprehensively, and the results wereof the acicular ferrite structures and considerably contributed to the improvement of the mechanical properties

Keywords： austempered ductile iron (ADI)     vanadium alloying     mechanical properties     crankshafts     retained austenite    

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Assessment and prediction of the mechanical properties of ternary geopolymer concrete

Jinliang LIU; Wei ZHAO; Xincheng SU; Xuefeng XIE

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 11,   Pages 1436-1452 doi: 10.1007/s11709-022-0889-y

Abstract: The experimental results were then compared with the predictions based on models of mechanical propertiesthe specific ranges (5% to 7% and 1.1 to 1.5, respectively) had positive effects on the mechanical propertiesFitting models, considering the effects of AC and AAM, were also proposed to predict the mechanical properties

Keywords： Ternary Geopolymer Concrete (TGC)     alkaline activator modulus     alkali content     mechanical properties    

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Molecular dynamics investigation of mechanical properties of single-layer phagraphene

Ali Hossein Nezhad SHIRAZI

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 2,   Pages 495-503 doi: 10.1007/s11709-018-0492-4

Abstract: two-dimensional (2D) full carbon allotrope with very interesting mechanical, electronic, optical, and thermal propertiesThe objective of this study is to investigate the mechanical properties of this new graphene like 2DIn this work, mechanical properties of phagraphene have been studied not only in the defect-free formWe studied different crack lengths to explore the influence of defects on the mechanical properties ofWe also investigated the temperature effect on the mechanical properties of pristine and defective phagraphene

Keywords： phaqraphene     mechanical properties     crack propaqation     molecular dynamics     thermal effects    

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Analysis of physical properties of gas hydrate-bearing unconsolidated sediment samples from the ultra-deepwater

Frontiers in Energy 2022, Volume 16, Issue 3,   Pages 509-520 doi: 10.1007/s11708-021-0786-4

Abstract: Laboratory measurements of various physical properties of gas hydrate-bearing marine sediments can provide

Keywords： natural gas hydrates     physical properties analysis     hydrate-bearing sediments    

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Title Author Date Type Operation

Biological properties and clinical applications of berberine

Danyang Song, Jianyu Hao, Daiming Fan

Journal Article

Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

Journal Article

Cell Therapy: Pharmacological Intervention Enters a Third Era

Wei He

Journal Article

A novel intravenous general anesthetic--- emulsified isoflurane: from bench to bedside

Cheng Zhou, Jin Liu

Journal Article

design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

Journal Article

Effect of different high viscosity modifiers on rheological properties of high viscosity asphalt

Journal Article

LINKING CROP WATER PRODUCTIVITY TO SOIL PHYSICAL, CHEMICAL AND MICROBIAL PROPERTIES

Journal Article

Effect of earth reinforcement, soil properties and wall properties on bridge MSE walls

Journal Article

Mechanical properties and microstructure of multilayer graphene oxide cement mortar

Journal Article

Synthesis, characterization and assessment thermal properties of clay based nanopigments

Mohammad Banimahd KIEVANI, Milad EDRAKI

Journal Article

Aging properties and aging mechanism of activated waste rubber powder modified asphalt binder based onrheological properties and micro-characterization

Journal Article

Mechanical properties of vanadium-alloyed austempered ductile iron for crankshaft applications

Journal Article

Assessment and prediction of the mechanical properties of ternary geopolymer concrete

Jinliang LIU; Wei ZHAO; Xincheng SU; Xuefeng XIE

Journal Article

Molecular dynamics investigation of mechanical properties of single-layer phagraphene

Ali Hossein Nezhad SHIRAZI

Journal Article

Analysis of physical properties of gas hydrate-bearing unconsolidated sediment samples from the ultra-deepwater

Journal Article